Lincomycin Hydrochloride Capsules 500mg

• Application: Internal Medicine
• Usage Mode: For oral administration
• Suitable for: Elderly, Children, Adult
• State: Solid
• Shape: Capsules
• Type: Organic Chemicals
• Model NO.: 500mg
• Pharmaceutical Technology: Chemical Synthesis
• Transport Package: Carton
• Specification: 500mg/capsule, 3x4capsules/box
• Trademark: RYAN PHARMA
• Origin: China

Product Description

Lincomycin Hydrochloride Capsules 500mg
THERAPEUTIC CLASS:
Antibacterial, Lincosamides.
COMPOSITION:
Each capsule contains:
Lincomycin Hydrochloride B.P. equivalent to Lincomycin 500mg.
Excipients QS.
PHARMACOLOGY:
Lincomycin is a lincosamide used in the treatment of severe anaerobic infection caused by bacteroides and other anaerobes that often participate in mixed infections. Depending on the sensitivity of the micro­organism, and the concentration of the antibiotic, Lincomycin may either be bacteriostatic or bactericidal.
The Invitro spectrum Includes the following micro­organism.
Sensitive microorganisms (MIC ≤-2 ug/m).
Anaerobic non sporulating gram-positive bacteria e.g. Actinomyces Spp, propionic bacterium Sppt and Eubacterium Spp.
Anaerobic and micro-aero foil gram-positive cocci e.g. Peptocoicus Spp, Pepto streptococcus and micro-aerophilic streptococci.
INDICATIONS:
Severe infections due to susceptible microorganism bone and connective tissue Infections, Respiratory tract Infections, Urogenital infections, Skin and soft tissue Infections.
CONTRA-INDICATIONS:
Hypersensitivity to Lincomycin or Clindamycin, moniliasis, severe-liver or kidney damage.
PRECAUTIONS/WARNINGS:
G.I diseases especially colitis, asthma, history of allergies, newborn pregnancy, periodic LFT and blood counts, during prolonged therapy.
KEEP ALL MEDICINE OUT OF THE REACH OF CHILDREN.
INTERACTIONS:
Lincomycin has neuromuscular blocking activity in high doses and may enhance the effects of other drugs with this action, with a potential danger of respiratory depression; Lincomycin may antagonize the activity of Para sympathomimetic.
ADVERSE EFFECTS:
Diarrhoea (discontinue treatment) nausea, vomiting, abdominal discomfort, oesophagitis, antibiotic associated colitis, rashes, pruritus, urticaria and rarely anaphylaxis: Steven - Johnson's syndrome, exfoliate and vesiculobullous dermatitis, jaundice and altered liver function tests and thrombocytopenia, pain, induration and abscess after I.M Injection, thrombophlebitis after Intravenous Injection.
DOSAGE & ADMINISTRATION:
By mouth, adult and children over 14 years, 500 mg 3 - 4 times daily, depending on the severity of the Infection, Capsules not recommended for children below 14 years of age.
SYMPTOMS OF OVER DOSAGE AND ANTIDOTE:
Symptoms of overdose with lincomycin may include: leucopenia, agranulocytosis, eosinophilia, thrombocytopenia, erythema, multiforme, exfoliative and vesiculobullous dermatitis, polyarthritis and severe diarrhoea (in 20% or patients).
Lincomycin should be withdraw immediately If significant diarrhoea or colitis occurs, Metronidazole or vancomycin may i.e. used to treat antibiotic associated pseudomembranous colitis.
STORAGE/HANDLING RECOMMENDATIONS:
Store at controlled room temperature (15-30ºC).