Aminophylline Injection 250MG/ 10ML COMPOSITION: Contains Aminophylline 250mg in 10mL. PHARMACOLOGICAL CLASSIFICATION: A.10.2. (Bronchodilator). PHARMACOLOGICAL ACTION: Uniphyllin (Aminophylline) relaxes smooth muscle and relieves bronchospasm. Aminophylline is more soluble than pure theophylline. INDICATIONS: Relief of bronchospasm associated with asthma, bronchitis and emphysema. CONTRA-INDICATIONS: Hypersensitivity to Bunaphyllin (Aminophyllline). WARNINGS: There is evidence that Bunaphyllin (Aminophylline) acts synergistically with ephedrine and this must be taken into account if the two drugs are prescribed together. Some children may be unusually sensitive to Bunaphyllin (Aminophylline). Safe use of Bunaphyllin (Aminophylline) in pregnancy has not been established. DOSAGE AND DIRECTIONS FOR USE: Intravenous Adults 250-500 mg. Children 6-12 years: 50-100 mg. The solution should be warmed to body temperature and must be injected slowly. SIDE-EFFECTS AND SPECIAL PRECAUTIONS: The side-effects commonly encountered with theophylline and its derivatives are gastrointestinal irritation and stimulation of the central nervous system. Bunaphyllin (Aminophylline) may cause nausea, vomiting, gastrointestinal bleeding, visual disorders, insomnia, headache, anxiety, confusion restlessness, hyperventilation, vertigo,and palpitations. KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: Overdosage may lead to maniacal behaviour,repeated vomition with extreme thirst, delirium, hyperthermia, and convulsions. Hypotension may follow intravenous injection, particularly if the injection is too rapid, and sudden deaths have been reported. Treatment is symptomatic and supportive. Fluid and electrolyte balance should be maintained with intravenous fluids and oxygen given as necessary. Convulsions should be controlled by the intravenous administration of diazepam 5 or 10mg or, if necessary, thiopentone sodium. IDENTIFICATION: Clear colourless solutions in ampoules. PRESENTATION: Intravenous 10mL ampoules, 50' s or 100' s. STORAGE INSTRUCTIONS: Store below 25ºC. Protect from light. Keep all medicines out of reach of children.
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