Vitamin B Complex Injection 2ml COMPOSITION: Each 2mL contains: Vitamin B1 20mg Vitamin B6 2mg Vitamin B2 2mg Nicotinamide 30mg Sodium-Pantothenate 1mg Excipients: q.s. CHEMISTRY: Thiamine Hydrochloride is 3- [(4-amino-2-methylpyrimidin-5-yl) methyl]- 5 -(2-hydroxyethyl) -4-methylthiazolium chloride hydrochloride. Riboflavin is 7,8-Dimethyl-10-[ (2S,3S,4R)-2,3,4,5-tetrahydroxypentyl] benzo [g] pteridine-2,4(3 H, 10H)-dione. Pyridoxine Hydrochloride is 5-hydroxy-6-methylpyridine-3, 4-dimethanol hydrochloride. Nicotinamide is pyridine- 3-carboxamide. Sodium-Pantothenate is calcium sodium(R)-N-(2,4-dihydroxy-3, 3-dimethyl-1-oxobutyl) -β-alaninate. INDICATIONS: Thiamine is an essential coenzyme for carbohydrate metabolism. Thiamine deficiency develops when the dietary intake is inadequate; severe deficiency leads to the development of a syndrome known as beriberi. Chronic 'dry' beriberi is characterized by peripheral neuritis, bradycardia muscle weakness and para1ysis. Acute 'wet' beriberi is characterized by cardiac failure and oedema. Demyelination of the central nervous system may develop in severe cases of thiamine deficiency. Riboflavin is essential for the utilization of energy from food. The active flavin mononucleotide and flavin adenine dinucleotide are involved as coenzymes in oxidative/reductive metabolic reaction. Riboflavin deficiency develops when the dietary intake is inadequate. Deficiency leads to the development of a well-defined syndrome known as ariboflavinosis, characterized by cheilosis, angular stomatitis, glossitis and seborrheic keratosis of the nose and anogenital region. There may also be ocular symptoms including itching and burning of the eyes, photophobias and corneal vascularization. Pyridoxine is involved principally in amino acid metabolism, but is also involved in carbohydrate and fat metabolism. It is also required for the formation of hemoglobin. Pyridoxine deficiency in adults leads to the development of peripheral neuritis, deficiency in children also affects the CNS. It is used in the treatment sideroblastic enemies, in certain metabolic disorders. Nicotinamide and Nicotinic acid occur naturally in the body are vitamin B substances, which are converted to nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). These coenzymes are involved in electron transfer reaction in the respiratory chain. Nicotinamide and Nicotinic acid are used in the treatment and prevention of nicotinic acid deficiency. Its deficiency develops when the dietary intake is inadequate. Deficiency leads to the development of the syndrome known as pellagra, characterized by skin lesion, especially on areas exposed to sunlight. with hyperpigmentation and hyperkeratinization. Other symptoms include diarrhea, abdominal pain, glossitis, stomatitis, loss of appetite, headache, lethargy, and mental and neurological disturbances. De-panthenol is the alcoholic of D-Pantothenic acid and is considered to be a vitamin B substance. It has been used in a variety of conditions including controlling gastrointestinal atony. CONTRA-INDICATIONS: It is contra-indicated in hemophiliacs and in patients with ileus due to mechanical obstruction. ADVERSE EFFECTS: Rarely hypersensitivity reactions or allergy and other side effects are associated with long term administration of large doses. ADMINISTRATION: It may be given by intramuscular or intravenous injection in dose of 2 mL or mono daily for adults. Or in a dose decided by a registered medical practitioner only. PACKING: Ampoules of 2ml-box of 10 ampoules. STORAGE: Store below 25ºC. Protect from light. KEEP OUT OF REACH OF CHILDREN. SHELFLIFE: 3 years.
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