| Application: | Internal Medicine |
|---|---|
| Usage Mode: | For oral administration |
| Suitable for: | Elderly, Children, Adult |
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Doxycycline Tablets 200 mg
PRESENTATION:
Box of l x 8's tablets
COMPOSITION:
Each film-coated tablet contains:
Doxycycline hyclate USP
equivalent to Doxycycline 200 mg
INDICATIONS:
Doxycycline tablet indicated for Infections caused by susceptible strains.
* Upper and lower respiratory tract:
Sinusitis, pharyngitis, pneumonia (Legionella and Mycoplasma) and psittacosis;
* Genito-urinary tract:
Non-specific urethritis, lymphogranuloma venereum, chancroid and granuloma inguinale,
gonorrhoea, gonococcal salpingitis, epididymitis acute epididymo-orchitis, endocervical
infections and syphilis
* Ophthalmic:
Trachoma and inclusion conjunctivitis
* Intestinal
Cholera, Whipple's disease, and tropical sprue.
CONTRA-INDICATIONS:
Hypersensitivity to doxycycline or any of the other tetracyclines. Do not administer
doxycycline during pregnancy. Doxycycline crosses the placenta and is deposited in foetal bones
and teeth and may lead to permanent grey-yellow-brown discolouration of the teeth. Pregnant
women are particularly susceptible to severe doxycycline induced liver damage. Do not
administer to lactating women or to children younger than 12 years of age as permanent
discolouration of the child's teeth may occur. Do not give to patients suffering from systemic
lupus erythematosus.
WARNINGS AND PRECAUTIONS:
Warnings:
Use with care in patients with impaired liver function. Frail or elderly patients are susceptible to
the hepatotoxic and anti-anabolic effects of doxycycline Do not use concomitantly with
hepatotoxic medicines. Symptoms of Myasthenia gravis may be aggravated. Photosensitivity
may occur. Raised intracranial pressure may occur, particularly in infants and especially if
Vitamin A or other retinoids are given concomitantly.
Precaution:
All patients taking doxycycline should be advised:
to avoid excessive sunlight or artificial ultraviolet light while receiving doxycycline and to
discontinue therapy if phototoxicity (e.g-, skin eruption, etc.) occurs. Sunscreen or sunblock
should be considered.
to drink fluids liberally along with doxycycline to reduce the risk ofesophageal irritation and
ulceration.
that the absorption of tetracyclines is reduced when taken with foods, especially those which
contain calcium. However, the absorption of doxycycline is not markedly influenced by
Simultaneous ingestion of food or milk.
that the absorption of tetracyclines is reduced when taking bismuth subsalicylate
that the use of doxycycline might increase the incidence of vaginal candidiasis
Patients should be counseled that antibacterial drugs including doxycycline hyclate should
only be used to treat bacterial infections. They do not treat viral infections (e.g, the common
cold).
SIDE EFFECTS
Diarrhea, anorexia, nausea, vomiting, diarrhoea, glossitis, dysphagia, enterocolitis, and
inflammatory lesions in the anogenital region, Hepatotoxicity esophageal ulcerations, toxic
epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, maculopapular and
erythematous rashes, exfoliative dermatitis, Renal toxicity,urticaria, angioneurotic edema,
anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic
lupus erythematosus, Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia,
bulging fontanels in infants, intracranial hypertension in adults.
STORAGE INSTRUCTIONS:
Protect from heat and moisture
Keep out of reach of children.
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